In order to support evidence-based fertilizer recommendations, agricultural production, and food security, the Regional Hub for Fertilizer and Soil Health for West Africa and the Sahel is striving to improve national soil and plant laboratory capacities. Evaluations conducted in five nations—Nigeria, Ghana, Sierra Leone, Liberia, and Togo—found enduring deficiencies in infrastructure, data administration, technical know-how, quality control, and laboratory equipment. Through enhanced accreditation mechanisms, staff training, standardized analytical processes, and equipment updates, the project fills in these gaps. The creation of Liberia’s first fully operational reference soil laboratory, created in partnership with the University of Liberia and the Soils4Liberia initiative, is a significant accomplishment. Plans to increase collaboration with Côte d’Ivoire, Senegal, Mali, and Niger are intended to create a regional network of reference laboratories, enhance the accuracy of soil data, and promote sustainable food systems and climate-resilient agriculture throughout West Africa and the Sahel.