Over 30 million Sahelians, most of whom are women and children, will require lifesaving assistance and protection in 2022, an increase of almost two million from 2021. Burkina Faso, Cameroon (Far North), Chad, Mali, Niger, and Nigeria (North-East) have developed Response Plans for 2022, requiring a total of US $3.8 billion. To scale up aid operations, coordination, adequate resources, and a principled response are all critical.